Ice 'n Ezy Ice Packs can be very effective in the treatment of headaches and migraines. Whether to apply the ice pack hot or cold is a matter of preference, with many people stating either method is equally effective. Hot or cold packs generally provide the greatest relief when applied to the head or to the back of the neck. If using a heated ice pack, wrap it in a towel to ensure that too much heat isn't applied directly to the area.